Folate Metabolism DNA Test | MTHFR C677T Gene | At Home Cheek Swab Sample Collection Kit | Results in 10-15 Working Days from AffinityDNA

The DNA test for folate metabolism evaluates your body’s ability to metabolize folic acid and other forms of folate. Specifically, this test analyzes the MTHFR C677T gene (Methylenetetrahydrofolate Reductase), which codes for an enzyme involved in converting folic acid into its active form, called 5-Methyltetrahydrofolate (5-MTHF). The active form of folate is essential for DNA synthesis, cell repair, and neurotransmitter production. A reduced ability to metabolize folates can affect various aspects of health, such as the risk of neural tube defects during pregnancy, cardiovascular issues, and other conditions linked to elevated homocysteine levels in the blood. Folate metabolism is how our body uses vitamin B9 to perform important functions: Absorption: When we eat foods rich in folates, like leafy greens, they are absorbed in the small intestine. Conversion: Once absorbed, folates are converted into an active form called tetrahydrofolate (THF), which the body can use. DNA Synthesis: THF helps produce DNA, essential for cell growth and division. Red Blood Cell Formation: It also helps create red blood cells, which carry oxygen through the blood. Amino Acid Metabolism: THF contributes to converting certain amino acids, the building blocks of proteins. Methylation: Folates help regulate gene function by turning them on or off, ensuring proper cell function. If there is not enough folate in the body, problems like anemia (low healthy red blood cells) or, during pregnancy, fetal malformations may occur. The MTHFR C677T variant is a genetic mutation that can make folate metabolism less efficient. People with this variant may have difficulty converting folic acid (the synthetic version of vitamin B9) and dietary folates into 5-MTHF, the active form the body uses. This can increase the risk of elevated homocysteine levels, linked to heart problems, and negatively affect the ability to metabolize folic acid. How Our Test Works: Green indicates that the variants identified in the analysis do not unfavourably alter the enzyme activity of the protein they encode and/or the risk associated with certain diseases. Orange indicates that the variants identified in the analysis slightly unfavourably alter enzyme activity and/or the risk associated with certain disorders or diseases. Red indicates that the variants identified in the analysis alter enzyme activity in a particularly unfavourable way, resulting in an increased risk of developing certain disorders or associated diseases. Test Results Include analysis MTHFR C677T variant that influence folate metabolism. Please see the images for an extract of an example report.

• The Folate Metabolism Test test is a science-based DNA test helps to determine if a person is at higher risk for issues like elevated homocysteine, which is linked to a greater risk of cardiovascular diseases, and may have trouble properly metabolizing folic acid.
• Simply take the easy, at-home test and in just 10-15 working days you will receive a comprehensive genetic report from the laboratory that gives you recommendations - based on your unique DNA
• The Folate Metabolism test can shed new light on your risk of folate deficiency, cardiovascular health, pregnancy and foetal development, personalized nutrition, neurological and mental health, our DNA test kit can provide you with the answers you need.
• The Folate Metabolism test analyses the MTHFR C677T gene, known to influence several important health aspects, particularly related to folate metabolism and homocysteine levels. Please see the images for an extract of an example report.